Specific Language Impairment Genes, Variants and Possible Gene-based Interventions

نویسندگان

چکیده

Specific Language Impairment (SLI) is a communication neurodevelopmental disorder that manifests at the age of 3-5 years when child lags his chronological speech development by one year in absence medical, environmental, and psychological risk factors. SLI has been known to be highly heritable. Many studies have demonstrated different genes loci implicated through linkage studies, commonest which were, FOXP2, ATP2C2, CMIP, CNTNAP2, DCDC2, KIAA0319, DYX1C1, SRPX2, NFXL1, ERC1, SETBP1, SEMA6D, AUTS2, GRIN2A B. In this review, we aim present comprehensive summary reported responsible or correlated common non-synonymous variants for each gene their potential pathophysiological impact on normal development.

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ژورنال

عنوان ژورنال: Suez Canal University Medical Journal (Print)

سال: 2021

ISSN: ['1110-6999', '2090-2581']

DOI: https://doi.org/10.21608/scumj.2021.155491